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Tissue Engineering and Regenerative Medicine Potentialities of Materials - Based Novel Constructs - A Review

[ Vol. 6 , Issue. 1 ]

Author(s):

Hafiz M.N. Iqbal, Kuldeep Dhama, Ashok Munjal, Rekha Khandia, Kumaragurubaran Karthik, Maryam Dadar, Swati Sachan, Shyma K. Latheef and Sunil K. Joshi   Pages 29 - 40 ( 12 )

Abstract:


Background: In recent years, tissue engineering (TE) and regenerative medicine (RM) are rapidly evolving fields. TE and RM are part of the biomedical field, and both are emergent research areas with a high impact on medical issues. The development of new types of novel, effective and highly reliable engineering constructs is essential to tackle many human health-related diseases. To this end, materials science technology offers an excellent engineering exploitability.

Objective: The objective of this review is to extend the current knowledge in the field of biomaterials for TE and RM including human-made novel constructs though using different materials and strategies.

Methods: We extensively reviewed, analyzed and compiled salient information from the authentic published literature available in PubMed and other scientific databases.

Results: The multi-shape novel constructs have been fabricated for a variety of applications in bio and non-bio sectors of the modern world. As compared to the natural bulk material, engineering of their constructs particularly at the micro and nano-level impart unique characteristics including surface area and surface functionality enhancement, improved thermo-mechanical and electrical conductivity, etc. The materials-based engineered constructs have been exploited in biotechnology at large and biomedical in particular.

Conclusion: The most promising applications include their utilization as a vehicle to deliver therapeutic agents, as scaffolds for engineering various tissues and also serve as an integrated part of biomedical implants, etc. Herein, we reviewed bio-nano-technological advancements from a TE and RM perspective in particular and envision directions of future developments.

Keywords:

Biomaterials, bone tissue engineering, heart tissue engineering, novel constructs, organs, regeneration, skin tissue engineering, tissue engineering.

Affiliation:

School of Engineering and Science, Tecnologico de Monterrey, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, N. L., CP 64849, Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, Uttar Pradesh, Department of Biochemistry and Genetics, Barkatullah University, Bhopal, Madhya Pradesh, Department of Biochemistry and Genetics, Barkatullah University, Bhopal, Madhya Pradesh, Central University Laboratory, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Immunology Section, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, Immunology Section, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, Cellular Immunology Lab, Frank Reidy Research Center of Bioelectrics, College of Health Sciences, Old Dominion University, VA 23529, Norfolk



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